Monoclonal Antibody BA4 Does Not Bind to Hematopoietic Precursor Cells
نویسندگان
چکیده
Monoclonal antibody BA-i binds to B lymphocytes, to cells from most cases of non-T acute lymphoblastic leukemia (ALL). and weakly to neutrophils. To determine whether BA-i also reacts with hematopoietic progenitor cells (HPC), we studied the effect of removal of BA-i cells from human bone marrow on the proliferation in vitro of the trilineage precursor cell CFU-GEMM, and of the committed progenitor cells of granulopoiesis (CFU-C) and erythropoiesis (BFU-E/CFU-E). Complement-mediated cytotoxicity using BA-i at concentrations far beyond those required to lyse BA-i bone marrow cells and ALL cells did not result in
منابع مشابه
Monoclonal antibody BA-1 does not bind to hematopoietic precursor cells.
Monoclonal antibody BA-1 binds to B lymphocytes, to cells from most cases of non-T acute lymphoblastic leukemia (ALL), and weakly to neutrophils. To determine whether BA-1 also reacts with hematopoietic progenitor cells (HPC), we studied the effect of removal of BA-1+ cells from human bone marrow on the proliferation in vitro of the trilineage precursor cell CFU-GEMM, and on the committed proge...
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تاریخ انتشار 2005